Localized adenovirus gene delivery using antiviral IgG complexation

  title={Localized adenovirus gene delivery using antiviral IgG complexation},
  author={Robert J. Levy and Cunxian Song and Sruthi Tallapragada and Suzanne Defelice and J Travis Hinson and Naren Vyavahare and Jeanne Connolly and Kenneth Ryan and Qian Li},
  journal={Gene Therapy},
Gene therapy with viral vectors has progressed to clinical trials. However, the localization of viral vector delivery to diseased target sites remains a challenge. We tested the hypothesis that an adenoviral vector could be successfully delivered by complexation with a specific antibody that is bound to a biodegradable matrix designed for achieving localized gene transduction. We report the first successful delivery system based upon antibody immobilization of virions in a type I collagen… CONTINUE READING


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