Localized Na+/H+ exchanger 1 expression protects Ca2+-regulated adenylyl cyclases from changes in intracellular pH.

@article{Willoughby2005LocalizedNE,
  title={Localized Na+/H+ exchanger 1 expression protects Ca2+-regulated adenylyl cyclases from changes in intracellular pH.},
  author={Debbie Willoughby and Nanako Masada and Andrew J Crossthwaite and Antonio Ciruela and Dermot M F Cooper},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 35},
  pages={
          30864-72
        }
}
The Ca2+-sensitive adenylyl cyclases (ACs) are exclusively regulated by capacitative Ca2+ entry (CCE) in nonexcitable cells. The present study investigates whether this Ca2+-dependent modulation of AC activity is further regulated by local pH changes that can arise beneath the plasma membrane as a consequence of cellular activity. Ca2+ stimulation of AC8 expressed in HEK 293 cells and inhibition of endogenous AC6 in C6-2B glioma cells exhibited clear sensitivity to modest pH changes in vitro… CONTINUE READING

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