Localized L-type calcium channels control exocytosis in cat chromaffin cells

  title={Localized L-type calcium channels control exocytosis in cat chromaffin cells},
  author={Manuela Garc{\'i}a L{\'o}pez and Almudena Albillos and Mar{\'i}a Teresa de la Fuente and Ricardo Borges and Luis M. Gandia and Emilio Carbone and Antonio G Garc{\'i}a and Antonio R. Artalejo},
  journal={Pfl{\"u}gers Archiv},
Depolarizing 1-s pulses to 0 mV from a holding potential of −70 mV, induced whole-cell currents through Ca2+ channels (I Ca) in patch-clamped cat adrenal medulla chromaffin cells. The dihydropyridine (DHP) furnidipine (3 μM) reduced the peak current by 47% and the late current by 80%. ω-Conotoxin GVIA (CgTx, 1 μM) reduced the peak I Ca by 42% and the late I Ca by 55%. Pulses (10 s duration) with 70 mM K+/2.5 mM Ca2+ solution (70 K+/2.5 Ca2+), applied to single fura-2-loaded cat chromaffin cells… CONTINUE READING


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