Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors.

@article{Volckaert2013LocalizedFE,
  title={Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors.},
  author={Thomas Volckaert and Alice Campbell and Erik A Dill and Changgong Li and Parviz Minoo and Stijn P. De Langhe},
  journal={Development},
  year={2013},
  volume={140 18},
  pages={3731-42}
}
Localized Fgf10 expression in the distal mesenchyme adjacent to sites of lung bud formation has long been thought to drive stereotypic branching morphogenesis even though isolated lung epithelium branches in the presence of non-directional exogenous Fgf10 in Matrigel. Here, we show that lung agenesis in Fgf10 knockout mice can be rescued by ubiquitous overexpression of Fgf10, indicating that precisely localized Fgf10 expression is not required for lung branching morphogenesis in vivo. Fgf10… CONTINUE READING

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