Localized Ca 2 uncaging reveals polarized distribution of Ca 2-sensitive Ca 2 release sites : mechanism of unidirectional Ca 2 waves

@inproceedings{Ashby2002LocalizedC2,
  title={Localized Ca 2 uncaging reveals polarized distribution of Ca 2-sensitive Ca 2 release sites : mechanism of unidirectional Ca 2 waves},
  author={Michael C. Ashby and Madeleine Craske and Myoung Kyu Park and Oleg V Gerasimenko and Robert D. Burgoyne and Ole H Petersen and Alexei V Tepikin},
  year={2002}
}
a 2 -induced Ca 2 release (CICR) plays an important role in the generation of cytosolic Ca 2 signals in many cell types. However, it is inherently difficult to distinguish experimentally between the contributions of messenger-induced Ca 2 release and CICR. We have directly tested the CICR sensitivity of different regions of intact pancreatic acinar cells using local uncaging of caged Ca 2 . In the apical region, local uncaging of Ca 2 was able to trigger a CICR wave, which propagated toward the… CONTINUE READING