Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts.

@article{Clohisy1996LocalizedTO,
  title={Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts.},
  author={Denis R. Clohisy and Christian M Ogilvie and Randall J. Carpenter and Margaret L. Ramnaraine},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={1996},
  volume={14 1},
  pages={
          2-6
        }
}
The cellular and biochemical mechanisms that direct destruction of bone at the site of tumor osteolysis are unknown. In order to understand this process better, a murine model designed for the study of tumor osteolysis was developed and the influence of osteolytic and nonosteolytic tumors on bone was investigated. Tumors developed following femoral intramedullary injection of sarcoma (2472) and melanoma (G3.26) cell lines; however, only tumors from the 2472 cell line caused osteolysis. It was… CONTINUE READING

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