Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration

@article{Bonadio1999LocalizedDP,
  title={Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration},
  author={Jeffrey Bonadio and Elizabeth C Smiley and Pravin Patil and Steven T. Goldstein},
  journal={Nature Medicine},
  year={1999},
  volume={5},
  pages={753-759}
}
The inability to deliver growth factors locally in a transient but sustained manner is a substantial barrier to tissue regeneration. Systems capable of localized plasmid gene delivery for prolonged times may offer lower toxicity and should be well-suited for growth factor therapeutics. We investigated the potency of plasmid gene delivery from genes physically entrapped in a polymer matrix (gene activated matrix) using bone regeneration as the endpoint in vivo. Implantation of gene activated… CONTINUE READING
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