Localization to the nucleolus is a common feature of coronavirus nucleoproteins, and the protein may disrupt host cell division.

@article{Wurm2001LocalizationTT,
  title={Localization to the nucleolus is a common feature of coronavirus nucleoproteins, and the protein may disrupt host cell division.},
  author={Torsten Wurm and Hong-wu Chen and Teri S. Hodgson and Paul Britton and Gavin Brooks and Julian A. Hiscox},
  journal={Journal of virology},
  year={2001},
  volume={75 19},
  pages={9345-56}
}
The subcellular localization of transmissible gastroenteritis virus (TGEV) and mouse hepatitis virus (MHV) (group I and group II coronaviruses, respectively) nucleoproteins (N proteins) were examined by confocal microscopy. The proteins were shown to localize either to the cytoplasm alone or to the cytoplasm and a structure in the nucleus. This feature was confirmed to be the nucleolus by using specific antibodies to nucleolin, a major component of the nucleolus, and by confocal microscopy to… CONTINUE READING