Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.

@article{Schulte2018LocalizationTD,
  title={Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.},
  author={Bianca Schulte and A. Selyutina and S. Opp and Alon Herschhorn and J. Sodroski and M. Pizzato and F. Diaz-Griffero},
  journal={Virology},
  year={2018},
  volume={515},
  pages={
          52-65
        }
}
SERINC5(S5) is a multi-span transmembrane protein that potently blocks the infectivity of HIV-1 produced by human T-cells. The ability of S5 to restrict infectivity correlates with its presence in the virion, but the exact mechanism by which S5 restricts HIV-1 is unknown. Here we tested whether the core from HIV-1 virions containing S5 is delivered to the cytoplasm. Using the "fate of the capsid" assay, we demonstrated that the viral core of S5-restricted HIV-1 does not reach the cytoplasm of… Expand
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