Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains.

@article{Belknap1995LocalizationTC,
  title={Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains.},
  author={John K. Belknap and Jeffrey S Mogil and Melinda L. Helms and Stephen P Richards and Laurie A. O'Toole and Susan E. Bergeson and Kari J. Buck},
  journal={Life sciences},
  year={1995},
  volume={57 10},
  pages={PL117-24}
}
A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (RI) strains and in an F2 cross (B6D2F2) between the BXD progenitor strains, C57BL/6 and DBA/2. A LOD score of 3.9 (p < .00002) was seen for analgesia using the hot plate assay. Naloxone Bmax was also associated with this chromosome region in BXD RI mice. The mu opioid receptor gene (Oprm) has… CONTINUE READING

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