Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.

@article{Langeland1990LocalizationOT,
  title={Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.},
  author={Nina Langeland and Anne Margrete Oyan and Howard S. Marsden and Alan Cross and Joseph Charles Glorioso and Lisa Jean Moore and Lars Haarr},
  journal={Journal of virology},
  year={1990},
  volume={64 3},
  pages={1271-7}
}
We have previously shown that aminoglycosides such as neomycin and the polyamino acids polylysine and polyarginine selectively inhibit the binding of herpes simplex virus type 1 (HSV-1) to the cellular receptor, whereas HSV-2 infection is unaffected. In the present study we took advantage of this difference between HSV-1 and HSV-2 by using HSV(-1)-HSV(-2) intertypic recombinants to locate a region on the HSV-1 genome encoding proteins affecting the binding of the virion to the cellular receptor… CONTINUE READING

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