Localization of white-matter lesions and effect of vascular risk factors in late-onset major depression.

@article{Dalby2010LocalizationOW,
  title={Localization of white-matter lesions and effect of vascular risk factors in late-onset major depression.},
  author={Rikke Beese Dalby and M M Chakravarty and J. Ahdidan and Leif S\orensen and Jesper Rene Frandsen and Kristjana Yr Jonsdottir and Elisabeth S Tehrani and Raben Rosenberg and Leif Ostergaard and Poul Videbech},
  journal={Psychological medicine},
  year={2010},
  volume={40 8},
  pages={1389-99}
}
BACKGROUND Several studies suggest that patients with late-onset major depression (MD) have an increased load of cerebral white-matter lesions (WMLs) compared with age-matched controls. Vascular risk factors such as hypertension and smoking may confound such findings. Our aim was to investigate the association between the localization and load of WMLs in late-onset MD with respect to vascular risk factors. METHOD We examined 22 consecutive patients with late-onset first-episode MD and 22 age… CONTINUE READING