Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal.

@article{Beauchamp1989LocalizationOT,
  title={Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal.},
  author={Robert Daniel Beauchamp and John A. Barnard and C M McCutchen and J A Cherner and Robert J Coffey},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={84 3},
  pages={1017-23}
}
Transforming growth factor alpha (TGF alpha) shares with epidermal growth factor (EGF) structural homology (35%), a common cell-surface membrane receptor (TGF alpha/EGF receptor), and a nearly identical spectrum of biological activity, including inhibition of gastric acid secretion. Herein, we report expression of TGF alpha mRNA in normal gastric mucosa of the adult guinea pig, rat, and dog. TGF alpha mRNA was also detected in matched surgically resected gastric mucosa and adjacent gastric… CONTINUE READING

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