Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma.

@article{HoltenAndersen2005LocalizationOT,
  title={Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma.},
  author={Mads Nikolaj Holten-Andersen and Ulla Hansen and Nils Bruenner and Hans J\orgen Nielsen and Martin Illemann and Boye Schnack Nielsen},
  journal={International journal of cancer},
  year={2005},
  volume={113 2},
  pages={198-206}
}
Tissue inhibitor of matrix metalloproteases 1 (TIMP-1) inhibits the proteolytic activity of matrix metalloproteases and hereby prevents cancer invasion. However, TIMP-1 also possesses other functions such as inhibition of apoptosis, induction of malignant transformation and stimulation of cell-growth. We have previously demonstrated that TIMP-1 is elevated in blood from colorectal cancer patients and that high TIMP-1 levels predict poor prognosis. To clarify the role of TIMP-1 in colorectal… CONTINUE READING

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