Localization of the transmembrane proteoglycan syndecan‐4 and its regulatory kinases in costameres of rat cardiomyocytes: A deconvolution microscopic study

@article{VanWinkle2002LocalizationOT,
  title={Localization of the transmembrane proteoglycan syndecan‐4 and its regulatory kinases in costameres of rat cardiomyocytes: A deconvolution microscopic study},
  author={W Barry VanWinkle and Mark B. Snuggs and Eugenio L. de Hostos and Louis Maximilian Buja and Anne Woods and John R. Couchman},
  journal={The Anatomical Record},
  year={2002},
  volume={268}
}
Syndecan‐4 (syn‐4), a transmembrane heparan sulfate‐containing proteoglycan, is unique among the four members of the syndecan family in its specific cellular localization to complex cytoskeletal adhesion sites, i.e., focal adhesions. During early phenotypic redifferentiation of neonatal cardiomyocytes in culture, immunolocalization reveals syn‐4 to be heavily concentrated in the perinuclear endoplasmic reticulum‐Golgi region, with little found at the peripheral regions. Subsequently, syn‐4… 

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