Localization of the site of major resistance to fluid transport in Bruch's membrane.

@article{Starita1997LocalizationOT,
  title={Localization of the site of major resistance to fluid transport in Bruch's membrane.},
  author={C Starita and A A Hussain and Anne Patmore and John Marshall},
  journal={Investigative ophthalmology & visual science},
  year={1997},
  volume={38 3},
  pages={762-7}
}
PURPOSE To determine the site of highest resistance to the movement of water across Bruch's membrane in humans. METHODS A hydraulic conductivity chamber was designed that enabled us to measure flow across Bruch's membrane while ablating its subepithelial aspect using an excimer laser (193 nm). When resistance was lost, samples were fixed and processed for electron microscopy. RESULTS Changes in the hydraulic conductivity of Bruch's membrane in response to the excimer-mediated sequential… CONTINUE READING

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