Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling.

@article{Renner2007LocalizationOT,
  title={Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling.},
  author={Ute Renner and Konstantin Glebov and Thorsten Lang and Ekaterina Papusheva and Saju Balakrishnan and Bernhard Keller and Diethelm W. Richter and Reinhard Jahn and Evgeni Ponimaskin},
  journal={Molecular pharmacology},
  year={2007},
  volume={72 3},
  pages={502-13}
}
In the present study, we have used wild-type and palmitoylation-deficient mouse 5-hydroxytryptamine(1A) receptor (5-HT1A) receptors fused to the yellow fluorescent protein- and the cyan fluorescent protein (CFP)-tagged alpha(i3) subunit of heterotrimeric G-protein to study spatiotemporal distribution of the 5-HT1A-mediated signaling in living cells. We also addressed the question on the molecular mechanisms by which receptor palmitoylation may regulate communication between receptors and G(i… CONTINUE READING
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