Localization of the motor hand area to a knob on the precentral gyrus. A new landmark.

  title={Localization of the motor hand area to a knob on the precentral gyrus. A new landmark.},
  author={Tarek A. Yousry and U. D. Schmid and Hatem Alkadhi and D. Schmidt and Aurelia Peraud and A. Buettner and Peter A. Winkler},
  journal={Brain : a journal of neurology},
  volume={120 ( Pt 1)},
Using functional magnetic resonance imaging (fMRI) we have evaluated the anatomical location of the motor hand area. The segment of the precentral gyrus that most often contained motor hand function was a knob-like structure, that is shaped like an omega or epsilon in the axial plane and like a hook in the sagittal plane. On the cortical surface of cadaver specimens this precentral knob corresponded precisely to the characteristic 'middle knee' of the central sulcus that has been described by… 

Localization of hand motor activation in Broca's pli de passage moyen.

The region of hand motor activation can be reliably identified on the surface of the brain by assessing anatomical relationships to nearby structures and blinded observers were able to identify the hand motor area reliably after instruction in using these surface landmarks.

Use of a Brain Navigator to Identify the Precentral Knob of the Precentral Gyrus in Normal Subjects

  • S. JangH. LeeEun Bi Choi
  • Medicine, Biology
    Medical science monitor : international medical journal of experimental and clinical research
  • 2022
This study showed that the anatomical location of the precentral knob in normal subjects could be identified using a brain navigator and this method may be used clinically for patients requiring neuromodulation.

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A higher myelin content of the precentral motor hand knob was associated with more rostral corticomotor presentations, with stronger task-related activation and a higher precision of movement timing during a visuomotor synchronization task.

Precentral Knob Corresponds to the Primary Motor and Premotor Area

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A strong relationship was identified between the PPM, whole-hand sensory and motor stimulation responses, and fMR imaging hand activation and this study aimed to clarify the function subserved by the P PM and further evaluate hand area function in the primary sensorimotor cortex.



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The proposition that the motor and sensory areas are much broader and more complex than they were thought to be in the classic teaching that originated with Sherrington and Cushing is reaffirmed.

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The superior frontal, precentral, and central sulci of fixed brain specimens were marked and then scanned by computed tomography to identify the anterior border of the precentral gyrus in both unmarked fixed brains and patients.

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Origin of somatosensory evoked scalp responses in man.

A group of patients who had selective cortical ablations for epilepsy afforded a unique opportunity in that some required excision of the somatosensory hand area, either alone, or in addition to other tissue, thus enabling us to compare the effects of such ablations, on the scalp response, with that of other cerebral excisions.

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It is concluded that blood oxygen level-dependent fMRI can localize areas of cortical function in patients undergoing treatment planning for gliomas so that therapy can be directed away from regions of residual function.

Topographical study of supratentorial brain tumors.

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