Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component

@article{ClarkMaguire1994LocalizationOT,
  title={Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component},
  author={S Clark-Maguire and Paul E Mains},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={126},
  pages={199 - 209}
}
Genetic evidence suggests that the product of the mei-1 gene of Caenorhabditis elegans is specifically required for meiosis in the female germline. Loss-of-function mei-1 mutations block meiotic spindle formation while a gain-of-function allele instead results in spindle defects during the early mitotic cleavages. In this report, we use immunocytochemistry to examine the localization of the mei-1 product in wild-type and mutant embryos. During metaphase of meiosis I in wild-type embryos, mei-1… CONTINUE READING

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