Localization of the human G-CSF gene to the region of a breakpoint in the translocation typical of acute promyelocytic leukemia

@article{Simmers2004LocalizationOT,
  title={Localization of the human G-CSF gene to the region of a breakpoint in the translocation typical of acute promyelocytic leukemia},
  author={R. Simmers and J. Smith and M. F. Shannon and G. Wong and A. Lopez and E. Baker and G. Sutherland and M. Vadas},
  journal={Human Genetics},
  year={2004},
  volume={78},
  pages={134-136}
}
SummaryThe colony-stimulating factors regulate growth, differentiation, and function of blood cells. The effect of granulocyte colony-stimulating factor (G-CSF) on myeloid leukemias is unique among colony-stimulating factors in driving the leukemic cells from a self-renewing malignant state to a mature differentiated phenotype with the concomitant loss of tumorigenicity. This property of G-CSF has led to suggestions that its absence is responsible for lack of differentiation of leukemic cells… Expand

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