Localization of the guinea pig eosinophil major basic protein to the core of the granule

@article{Lewis1978LocalizationOT,
  title={Localization of the guinea pig eosinophil major basic protein to the core of the granule},
  author={Daniel M. Lewis and Jon C. Lewis and David A. Loegering and Gerald J. Gleich},
  journal={The Journal of Cell Biology},
  year={1978},
  volume={77},
  pages={702 - 713}
}
The localization of the guinea pig eosinophil major basic protein (MBP) within the cell was investigated by the use of immunoelectron microscopy and by isolation of the granule crystalloids. First, by immunoperoxidase electron microscopy, we found that the MBP of eosinophil granules is contained within the crystalloid core of the granule. Specific staining of cores was present when rabbit antiserum to MBP was used as the first stage antibody in a double antibody staining procedure, whereas… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Physi712 ThE JOURNAL OF CELL B1OLOCV" VOLUME 77,1978 ochemical and biological properties of the major basic protein from guinea pig eosinophil granules

G. J. GLEICrt, D. A. LOEGERING, F. KUEVPERS, S. P. BAJAJ, K. G. MANN
  • J. Exp. Med
  • 1974
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

The hydrolysis of rabbit gamma globulin and antibodies with crystalline papain

R. R. PORTER
  • Biochem. J. 73:119-126
  • 1959
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Antiserum to the major basic protein of eosinophil granules, lmrnunochemistry

D. M. LEWIS, D. A. LOEGERIN, G. J. GLEICH
  • 1976
VIEW 2 EXCERPTS

Isolation and Partial Characterization of a Major Basic Protein from Rat Eosinophil Granules 1

  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1976
VIEW 1 EXCERPT