Localization of the gene responsible for Peutz-Jeghers syndrome within a 6-cM region of chromosome 19p13.3

@article{Nakagawa1998LocalizationOT,
  title={Localization of the gene responsible for Peutz-Jeghers syndrome within a 6-cM region of chromosome 19p13.3},
  author={Hidewaki Nakagawa and Kumiko Koyama and Toshihiro Tanaka and Yasuo Miyoshi and Hiroshi Ando and Shozo Baba and Masahiro Watatani and Masayuki Yasutomi and Morito Monden and Yusuke Nakamura},
  journal={Human Genetics},
  year={1998},
  volume={102},
  pages={203-206}
}
Patients with Peutz-Jeghers syndrome (PJS), an autosomal dominant disease characterized by hamartomatous polyposis of the gastrointestinal tract, are thought to be predisposed to malignancies of the digestive tract, genital tract, and other organs. Using microsatellite markers on chromosome 19p, we have closely defined the region containing the gene responsible for this disorder through linkage analysis in seven affected families. The lack of obligate recombinants at two of these loci, D19S883… CONTINUE READING