Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain.

@article{Richards1994LocalizationOT,
  title={Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain.},
  author={Allan James Richards and Lamya Al-Imara and Nigel P. Carter and Julie C. Lloyd and Margaret A. Leversha and F. M. Pope},
  journal={Genomics},
  year={1994},
  volume={22 1},
  pages={237-9}
}
Laminin is a basement membrane glycoprotein composed of three nonidentical chains, A, B1, and B2. Variant chains such as merosin and S-laminin have been found in different tissues. We have isolated a cDNA encoding a novel laminin A variant that hybridizes to a 6.45-kb mRNA. Using amplification of genomic DNA and flow-sorted chromosomes we have assigned the gene (LAMA4) for this new laminin A variant to chromosome 6. Fluorescence in situ hybridization of a YAC clone further localized the gene to… CONTINUE READING