Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region.

@article{Sarfarazi1998LocalizationOT,
  title={Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region.},
  author={Mansoor Sarfarazi and Anne Child and Detelina Z Stoilova and Glen Brice and Trushna Desai and Ovidiu C. Trifan and Darmalingum Poinoosawmy and Ronald Pitts Crick},
  journal={American journal of human genetics},
  year={1998},
  volume={62 3},
  pages={641-52}
}
One of the major causes of blindness is primary open-angle glaucoma, which affects millions of elderly people worldwide. Genetic studies have so far mapped three loci for the adult-onset form of this condition to the 2cen-q13, 3q21-q24, and 8q23 regions. Herein, we report the localization of a fourth locus, to the 10p15-p14 region, in one large British family with a classical form of normal-tension open-angle glaucoma. Of the 42 meioses genotyped in this pedigree, 39 subjects (16 affected… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 103 extracted citations

Similar Papers

Loading similar papers…