Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.

@article{Lever2009LocalizationOT,
  title={Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.},
  author={Isobel J Lever and Michelle Robinson and Mario Cibelli and Cleoper C Paule and P{\'e}ter S{\'a}ntha and Louis Teo Loon Yee and Stephen P. Hunt and Benjamin F Cravatt and Maurice R Elphick and Istv{\'a}n Nagy and Andrew C. Rice},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 12},
  pages={3766-80}
}
Fatty acid amide hydrolase (FAAH) is a degradative enzyme for a group of endogenous signaling lipids that includes anandamide (AEA). AEA acts as an endocannabinoid and an endovanilloid by activating cannabinoid and vanilloid type 1 transient receptor potential (TRPV1) receptors, respectively, on dorsal root ganglion (DRG) sensory neurons. Inhibition of FAAH activity increases AEA concentrations in nervous tissue and reduces sensory hypersensitivity in animal pain models. Using… CONTINUE READING

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