Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.

Abstract

The human c-ab1 oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph') chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph' chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5' of, or within, the c-ab1 oncogene. A… (More)

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Cite this paper

@article{Heisterkamp1983LocalizationOT, title={Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.}, author={Nora C Heisterkamp and James R Stephenson and John Groffen and Peter Hansen and Annelies J E M M de Klein and C. R. Bartram and Gerard C. Grosveld}, journal={Nature}, year={1983}, volume={306 5940}, pages={239-42} }