Localization of the biochemical site of action of testosterone on protein synthesis in the seminal vesicle of the rat.

  • J D WILSON
  • Published 1962 in The Journal of clinical investigation

Abstract

Although the administration of testosterone clearly causes marked diminution in nitrogen excretion (3) and results in increased protein deposition in kidney, liver, muscle, carcass, and accessory sex tissue (4), the mechanisms of this protein anabolic action are unexplained. While this effect of testosterone is probably the result of an enhancement of protein synthesis, previous attempts to elucidate this action have been complicated by two factors: first, the major enzymatic steps in the synthesis of protein have been described only in the past few years (5); and second, previous attempts to demonstrate an influence of testosterone on protein synthesis in several nonsexual tissues of the rat (6) and mouse (7, 8) have yielded differences which, although consistent, are very small. Several observations have suggested that the rat accessory sex organs might serve as suitable tissues for an exploration of the mechanisms by which testosterone influences protein metabolism. The accessory sex organs are very responsive to the administration of testosterone (9), and in fact, Scow has reported that as much as 25 per cent of the total weight gain induced by testosterone in castrated rats occurs in the sexual tissue (10). Furthermore, Greer has demonstrated that the rat prostate rapidly and selectively concentrates testosterone-4-C14 (11). The present report describes a study of the influence of testosterone administration on protein synthesis in the rat seminal vesicle. Evidence is presented that testosterone administration will en-

Cite this paper

@article{WILSON1962LocalizationOT, title={Localization of the biochemical site of action of testosterone on protein synthesis in the seminal vesicle of the rat.}, author={J D WILSON}, journal={The Journal of clinical investigation}, year={1962}, volume={41}, pages={153-61} }