Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction.

@article{Teis2002LocalizationOT,
  title={Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction.},
  author={David Teis and Winfried Wunderlich and Lukas A. Huber},
  journal={Developmental cell},
  year={2002},
  volume={3 6},
  pages={803-14}
}
Eukaryotic cells use the extracellular signal regulated kinase (ERK) cascade to connect cell-surface receptors to intracellular targets. Although various signals are routed through the ERK pathway, cells respond accordingly to a given stimulus. To regulate proper signal transduction, scaffolds and adaptors are employed to organize specific signaling units. The scaffold protein MP1 (MEK1 partner) assembles a scaffold complex in the ERK cascade. We show that p14 functions as an adaptor protein… CONTINUE READING
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