Localization of the GoLoco motif carrier regulator of G‐protein signalling 12 and 14 proteins in monkey and rat brain

@article{LpezAranda2006LocalizationOT,
  title={Localization of the GoLoco motif carrier regulator of G‐protein signalling 12 and 14 proteins in monkey and rat brain},
  author={Manuel F. L{\'o}pez-Aranda and Mar{\'i}a Jos{\'e} Acevedo and Francisco J Carballo and Antonia Guti{\'e}rrez and Zafar Uddin Khan},
  journal={European Journal of Neuroscience},
  year={2006},
  volume={23}
}
Regulator of G‐protein signalling (RGS)12 and ‐14 proteins possess the RGS domain, Ras‐binding domains and the GoLoco motif. Emerging evidence suggests that these proteins are involved in several cellular functions in addition to stimulation of GTPase activity of G‐protein α subunits. However, our understanding of the role of the two proteins in brain function remains marginal. Here, we have studied the expression pattern of RGS12 and RGS14 proteins in brain at regional, cellular and… 
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Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory.
Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain
TLDR
The results show that R GS14 mRNA and protein are upregulated throughout postnatal mouse development, and RGS14 protein exhibits a dynamic localization pattern that is enriched in hippocampus and primary olfactory cortex in the adult mouse brain.
Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain
TLDR
It is reported that RGS14 protein immunoreactivity is found both pre- and postsynaptically in multiple neuron populations throughout hippocampal area CA1 and CA2, caudate nucleus, putamen, globus pallidus, substantia nigra, and amygdala in adult rhesus monkeys.
Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2
TLDR
RGS proteins induce a conformational change in the Gα subunit that accelerates GTP hydrolysis, thereby effectively turning off signaling cascades mediated by GPCRs and is the canonical mechanism of action for RGS proteins, although many also possess additional functions and domains.
Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
TLDR
Sequence analysis of the 20 RGS proteins suggests four families of RGS: RZ, R4, R7 and R12 families, Included here is RGS4 for which a number of pharmacological inhibitors have been described.
Regulator of G protein signaling 14 ( RGS 14 ) is expressed pre-and postsynaptically in neurons of hippocampus , basal ganglia , and amygdala of monkey and human brain
TLDR
It is reported that RGS14 protein immunoreactivity is found both preand postsynaptically in multiple neuron populations throughout hippocampal area CA1 and CA2, caudate nucleus, putamen, globus pallidus, substantia nigra, and amygdala in adult rhesus monkeys.
Regulators of G-protein-signaling proteins: negative modulators of G-protein-coupled receptor signaling.
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity
TLDR
The current knowledge of specific RGS proteins that have been clearly demonstrated to serve critical roles in modulating synaptic signaling and plasticity throughout the brain are reviewed and their potential as future therapeutic targets are considered.
Neuronal Functions of Activators of G Protein Signaling
TLDR
The current knowledge on AGS proteins is reviewed in relation to their potential roles in neuronal regulations and they are found to play a major role in modulating the G protein signaling in neurons.
Role of a Gαi2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool
TLDR
It is reported that a splice variant of the Gαi2 protein, protein sG αi2, plays a crucial role in the maintenance of this D2-receptor pool, and is uncovered a novel mechanism regulating the density of cell surface D2 receptors.
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References

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TLDR
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