Localization of surfactant-associated proteins SP-A and SP-B mRNA in rabbit fetal lung tissue by in situ hybridization.

@article{WohlfordLenane1992LocalizationOS,
  title={Localization of surfactant-associated proteins SP-A and SP-B mRNA in rabbit fetal lung tissue by in situ hybridization.},
  author={Christine L. Wohlford-Lenane and Jeanne M. Snyder},
  journal={American journal of respiratory cell and molecular biology},
  year={1992},
  volume={7 3},
  pages={335-43}
}
Pulmonary surfactant is a lipoprotein substance, comprised of approximately 80% phospholipid and approximately 10% protein, that lowers surface tension at the air-alveolar aqueous interface. Surfactant is synthesized and secreted by alveolar type II epithelial cells where it is stored intracellularly in lamellar bodies. In the present study, we used the technique of in situ hybridization to localize the mRNA for two surfactant-associated proteins, SP-A and SP-B, in developing rabbit fetal lung… CONTINUE READING

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