Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.

@article{Nicolas1997LocalizationOS,
  title={Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.},
  author={Jean Paul Nicolas and Y Lin and G{\'e}rald Lambeau and Farideh Ghomashchi and Michel Lazdunski and Michael H Gelb},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 11},
  pages={7173-81}
}
We have shown previously that neurotoxic venom secretory phospholipases A2 (sPLA2s) have specific receptors in brain membranes called N-type receptors that are likely to play a role in the molecular events leading to neurotoxicity of these proteins. The sPLA2 found in honey bee venom is neurotoxic and binds to this receptor with high affinity. In this paper, we have used a number of mutants of bee venom sPLA2 produced in Escherichia coli to determine the structural elements of this protein that… CONTINUE READING

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References

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Showing 1-4 of 4 references

Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism (Kini, R. M., ed

  • G. Lambeau, M. Lazdunski
  • 1996

Interaction of Neurotoxic Bee Venom PLA2 with Its Receptor

  • P. J. Kraulis
  • J. Appl. Crystallogr. 24,
  • 1991

Cellular and Molecular Basis of Cholinergic Function (Dowdall

  • P. N. Strong
  • J. N.,
  • 1987

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