Localization of splenic B cells activated for switch recombination by in situ hybridization with Igamma1 switch transcript and Rad51 probes.

@article{Peakman1998LocalizationOS,
  title={Localization of splenic B cells activated for switch recombination by in situ hybridization with Igamma1 switch transcript and Rad51 probes.},
  author={Mark Peakman and Nancy Maizels},
  journal={Journal of immunology},
  year={1998},
  volume={161 8},
  pages={4008-15}
}
B cells are activated for switch recombination by signals from Th cells, but the site at which this first occurs in vivo has yet to be identified. By in situ hybridization of splenic sections using riboprobes specific for the Igamma1 switch transcript and Rad51 mRNA, we have visualized B cells that are newly activated for switch recombination and… CONTINUE READING