Localization of specific erythropoietin binding sites in defined areas of the mouse brain.

@article{Digicaylioglu1995LocalizationOS,
  title={Localization of specific erythropoietin binding sites in defined areas of the mouse brain.},
  author={Murat H Digicaylioglu and S Bichet and Hugo H. Marti and Roland H. Wenger and Luis Rivas and Christian R. K. D. Bauer and Martin Gassmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 9},
  pages={3717-20}
}
The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in response to hypoxia. Binding of EPO to the EPO receptor (EPO-R), a member of the cytokine receptor superfamily, controls the terminal maturation of red blood cells. So far, EPO has been reported to act mainly on erythroid precursor cells. However, we have detected mRNA encoding both EPO and EPO-R in mouse brain by reverse transcription-PCR. Exposure to 0.1% carbon… CONTINUE READING