Localization of sodium channels in intercalated disks modulates cardiac conduction.

@article{Kucera2002LocalizationOS,
  title={Localization of sodium channels in intercalated disks modulates cardiac conduction.},
  author={Jan P. Kucera and Stephan Rohr and Yoram Rudy},
  journal={Circulation research},
  year={2002},
  volume={91 12},
  pages={1176-82}
}
It is well known that the sodium current (I(Na)) and the degree of gap-junctional electrical coupling are the key determinants of action potential (AP) conduction in cardiac tissue. Immunohistochemical studies have shown that sodium channels (NaChs) are preferentially located in intercalated disks (IDs). Using dual immunocytochemical staining, we confirmed the colocalization of NaChs with connexin43 in cultures of neonatal rat ventricular myocytes. In mathematical simulations of conduction… CONTINUE READING
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