Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment.

@article{Jelinic2014LocalizationOR,
  title={Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment.},
  author={Maria Jelinic and Chen H Leo and Emiel D Post Uiterweer and Shaun L. Sandow and Jonathan H. Gooi and Mary E Wlodek and Kirk P. Conrad and Helena C Parkington and Marianne Tare and Laura J Parry},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 1},
  pages={275-87}
}
Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet receptors for relaxin, such as RXFP1, have only been localized to vascular smooth muscle. This study first aimed to localize RXFP1 in rat arteries and veins from different organ beds and determine whether receptors are present in endothelial cells. We then tested the hypothesis that region-specific vascular effects of relaxin may be influenced by the cellular… CONTINUE READING

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