Localization of receptor sites for insect-selective toxins on sodium channels by site-directed antibodies.

@article{Gordon1992LocalizationOR,
  title={Localization of receptor sites for insect-selective toxins on sodium channels by site-directed antibodies.},
  author={Dalia Gordon and Howard Moskowitz and Michael Eitan and Carol Warner and William A. Catterall and Eliahu Zlotkin},
  journal={Biochemistry},
  year={1992},
  volume={31 33},
  pages={7622-8}
}
Site-directed antibodies corresponding to conserved putative extracellular segments of sodium channels, coupled with binding studies of radiolabeled insect-selective scorpion neurotoxins, were employed to clarify the relationship between the toxins' receptor sites and the insect sodium channel. (1) The depressant insect toxin LqhIT2 was shown to possess two noninteracting binding sites in locust neuronal membranes: a high-affinity (KD1 = 0.9 +/- 0.6 nM) and low-capacity (Bmax1 = 0.1 +/- 0.07… CONTINUE READING

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