Localization of rat glycine receptor alpha1 and alpha2 subunit transcripts in the developing auditory brainstem.

@article{Piechotta2001LocalizationOR,
  title={Localization of rat glycine receptor alpha1 and alpha2 subunit transcripts in the developing auditory brainstem.},
  author={Kerstin Piechotta and Franco Weth and Robert J Harvey and Eckhard Friauf},
  journal={The Journal of comparative neurology},
  year={2001},
  volume={438 3},
  pages={336-52}
}
Glycine receptors (GlyRs), aside from GABA(A) receptors, mediate fast postsynaptic inhibition in the mammalian nervous system. Spatial and temporal expression of the genes encoding ligand-binding alpha subunits (alpha1-alpha4) and the structural beta subunit leads to the formation of various GlyR isoforms. Currently, the idea of the GlyRs containing the "adult" alpha1 subunit replacing those with the "neonatal" alpha2 subunit during early postnatal development predominates. Here, we describe… CONTINUE READING

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