Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.

@article{Mollinedo1993LocalizationOR,
  title={Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.},
  author={Faustino Mollinedo and Dolores P{\'e}rez-Sala and Consuelo Gajate and Benilde Jim{\'e}nez and Patrick Rodriguez and J C Lacal},
  journal={FEBS letters},
  year={1993},
  volume={326 1-3},
  pages={209-14}
}
The subcellular localization of rap proteins in resting human neutrophils was investigated by immunoblot analysis with specific anti-rap2 and anti-rap1 antibodies of the membrane proteins obtained from distinct subcellular fractions. Rap2 protein was mainly located in gelatinase-containing granules, whereas rap1 protein was detected both in gelatinase-containing granules and in fractions enriched in plasma membrane. Neither rap1 nor rap2 proteins were found in the cytosol or in azurophilic… CONTINUE READING
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