Corpus ID: 28154249

Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases.

@article{Kawahito1998LocalizationOQ,
  title={Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases.},
  author={Yutaka Kawahito and Grant W Cannon and Pércio S. Gulko and Elaine F. Remmers and Ryan E. Longman and Van R. Reese and Jianping P. Wang and Marie M. Griffiths and Ronald L. Wilder},
  journal={Journal of immunology},
  year={1998},
  volume={161 8},
  pages={
          4411-9
        }
}
Adjuvant-induced arthritis (AIA) in rats is a widely used autoimmune experimental model with many features similar to rheumatoid arthritis (RA). To identify potential genetic regulatory mechanisms in RA, we conducted genome-wide linkage analysis in F2 progeny of arthritis-susceptible Dark Agouti (DA) and relatively resistant Fischer 344 (F344) inbred rats. We compared the data with our previously reported investigation of collagen-induced arthritis (CIA), which was expanded in the follow-up… Expand
Evaluation of quantitative trait loci regulating severity of mycobacterial adjuvant-induced arthritis in monocongenic and polycongenic rats: identification of a new regulatory locus on rat chromosome 10 and evidence of overlap with rheumatoid arthritis susceptibility loci.
TLDR
F344 genomic regions at Aia1, Aia2, and Aia3 and the newly identified Aia5 contain genes that reduce Mbt-AIA severity in DA rats, which overlap rheumatoid arthritis-susceptibility loci in humans. Expand
Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females.
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Identification of a new quantitative trait locus on Chromosome 7 controlling disease severity of collagen-induced arthritis in rats
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A new non-MHC quantitative trait locus, Cia8, is described on rat Chromosome (Chr) 7 that controls collagen-induced arthritis severity in F2 progeny of DA and F344 inbred rats, and an updated localization of Cia4 on the same chromosome is presented. Expand
IDENTIFICATION OF GENES THAT REGULATE ARTHRITIS AND IgE PRODUCTION IN RAT AND HUMAN
TLDR
Genetic finemapping in 16 congenic and subcongenic strains in oil-induced arthritis demonstrated that the NKC is situated outside the arthritis-regulating region, thus excluding NKC as being Oia2. Expand
Identification of genes controlling collagen-induced arthritis in mice: striking homology with susceptibility loci previously identified in the rat.
TLDR
Analysis of 224 F2 intercross mice with 170 microsatellite markers in a genome-wide scan suggested 4 quantitative trait loci controlling arthritis susceptibility located on chromosomes 6, 7, 8, and 10, which all appeared to contain disease-promoting alleles derived from the DBA/1 strain. Expand
Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis
TLDR
Findings provide clues to how genetic factors by themselves, and in interaction with each other, regulate the development of a disease, which displays many similarities to RA. Expand
Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis.
TLDR
The data indicate that the variety of genetic elements regulating human autoimmune and rheumatic diseases may be much larger and more varied than originally envisioned. Expand
High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes.
TLDR
Test the hypothesis that NKC regulates arthritis, by performing advanced mapping of arthritis and additional phenotypes induced by an intradermal injection of incomplete Freund's adjuvant-oil, and establishing that alleles from DA confer arthritis susceptibility to inbred LEW.1AV1 and PVG. Expand
Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis.
TLDR
These data demonstrate the complexity of PGIA, where QTLs may be involved in multiple traits or even originate from a genetic background previously determined to be resistant. Expand
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