Localization of proteins to the 1,2-propanediol utilization microcompartment by non-native signal sequences is mediated by a common hydrophobic motif.

@article{Jakobson2015LocalizationOP,
  title={Localization of proteins to the 1,2-propanediol utilization microcompartment by non-native signal sequences is mediated by a common hydrophobic motif.},
  author={Christopher M. Jakobson and Edward Y. Kim and Marilyn F. Slininger and Alex Yu-Hung Chien and Danielle Tullman-Ercek},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 40},
  pages={
          24519-33
        }
}
Various bacteria localize metabolic pathways to proteinaceous organelles known as bacterial microcompartments (MCPs), enabling the metabolism of carbon sources to enhance survival and pathogenicity in the gut. There is considerable interest in exploiting bacterial MCPs for metabolic engineering applications, but little is known about the interactions between MCP signal sequences and the protein shells of different MCP systems. We found that the N-terminal sequences from the ethanolamine… CONTINUE READING
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