Localization of protein kinases by anchoring proteins: a theme in signal transduction.

@article{MochlyRosen1995LocalizationOP,
  title={Localization of protein kinases by anchoring proteins: a theme in signal transduction.},
  author={Daria Mochly-Rosen},
  journal={Science},
  year={1995},
  volume={268 5208},
  pages={247-51}
}
A fundamental question in signal transduction is how stimulation of a specific protein kinase leads to phosphorylation of particular protein substrates throughout the cell. Recent studies indicate that specific anchoring proteins located at various sites in the cell compartmentalize the kinases to their sites of action. Inhibitors of the interactions between kinases and their anchoring proteins inhibit the functions mediated by the kinases. These data indicate that the location of these… CONTINUE READING
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