Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung.

@article{Homma1995LocalizationOP,
  title={Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung.},
  author={Saburo Homma and Isao Nagaoka and Hitoshi Abe and Kazuhisa Takahashi and Kuniaki Seyama and Toshihiro Nukiwa and Satoru Kira},
  journal={American journal of respiratory and critical care medicine},
  year={1995},
  volume={152 6 Pt 1},
  pages={2084-9}
}
To better understand the mechanisms responsible for the increase in numbers of fibroblasts and increased collagen synthesis in fibrotic intestitial lung diseases, platelet-derived growth factor (PDGF)-A and PDGF-B, PDGF receptor-alpha and -beta, insulin-like growth factor I (IGF-I), and IGF-I receptor were evaluated immunohistochemically. Additionally, the messenger ribonucleic acids (mRNAs) for PDGF-A and PDGF-B, PDGF receptor-alpha and -beta, and IGF-I were investigated by in situ… CONTINUE READING
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