Localization of phosphorylated SMAD proteins in granulosa cells, oocytes and oviduct of female mice.

@article{Tian2010LocalizationOP,
  title={Localization of phosphorylated SMAD proteins in granulosa cells, oocytes and oviduct of female mice.},
  author={Xi Tian and Ashley N Halfhill and Francisco J Alvarez D{\'i}az},
  journal={Gene expression patterns : GEP},
  year={2010},
  volume={10 2-3},
  pages={105-12}
}
SMAD signaling is essential for follicular development. The distribution of activated (phosphorylated) SMADs during folliculogenesis has not been described in detail. The present results indicate that oocytes from preantral and antral follicles contain the mRNA for the receptor regulated Smads (-1, -2, -3, -5 and -9), Smad4 (co-SMAD), and Smad6 and Smad7 (inhibitory SMADs). Levels of Smad5, Smad6 and Smad7 mRNA decreased in fully-grown oocytes compared to growing oocytes. Immunostaining for… CONTINUE READING

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