Localization of pendrin in mouse kidney.

@article{Wall2003LocalizationOP,
  title={Localization of pendrin in mouse kidney.},
  author={Susan M. Wall and Kathryn A. Hassell and Ines E. Royaux and Eric D. Green and Judy Chang and Gregory L. Shipley and Jill W Verlander},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={284 1},
  pages={
          F229-41
        }
}
Pendrin is an anion exchanger expressed in type B intercalated cells of the cortical collecting duct (CCD). Whether pendrin localizes to other nephron segments with intercalated cells is unknown. Moreover, whether pendrin is expressed in proximal tubule is debated. Thus the distribution of pendrin mRNA and protein expression in mouse kidney was investigated by using light and electron microscopic immunohistochemistry and quantitative real-time PCR. We observed that pendrin mRNA is expressed… Expand
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How aldosterone and angiotensin II-induced signaling regulate pendrin and the contribution of pendrin-positive ICs in the kidney to distal nephron function and blood pressure is described. Expand
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  • Chemistry, Medicine
  • American journal of physiology. Renal physiology
  • 2016
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The signaling mechanisms that regulate pendrin abundance and function are summarized as well as the contribution of pendrin to distal nephron function, which may modulate blood pressure partly through its extrarenal effects. Expand
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  • 2015
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The results demonstrate that pendrin mRNA expression in the rat kidney is abundant and limited to the cortex, and pendrin is an apical Cl-/base exchanger in the kidney proximal tubule and CCD and mediates Cl- /OH, Cl/HCO3, and Cl--/formate exchange. Expand
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It is concluded that striking differences exist in the prevalence and distribution of the different types of intercalated cells in the CNT, ICT, and CCD of rat and mouse. Expand
Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion
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TLDR
Immunolocalization studies indicate that pendrin is an apical anion transporter in intercalated cells of CCDs and has an essential role in renal bicarbonate secretion. Expand
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TLDR
In situ hybridization showed rTSC1 transcripts were localized to short, convoluted tubule segments in the kidney cortex and Ultrastructural studies by immunoelectron microscopy showed the cotransporter protein to be localized predominately on apical microvilli of the distal convoluted tubules cells. Expand
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TLDR
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TLDR
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Results demonstrate the coexpression of H+-ATPase and band 3 in opposite plasma membrane domains of a subpopulation of intercalated cells that are probably the acid-excreting (type A) cells and probably include the bicarbonate-exCreting ( type B) cells. Expand
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TLDR
Assessment of the distribution of AE1 mRNA and protein in the two intercalated cell types using cells freshly isolated from the native epithelium gives no support to the concept that AE1 functions both as a basolateral and an apical anion exchanger in cortical collecting duct cells. Expand
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The possibility of hybrid cells that might combine alpha- and beta-cell transport proteins suggests a mechanism for functional reversal of collecting duct IC polarity. Expand
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It is concluded that three morphologically and immunologically distinct types of intercalated cells are present in the mouse kidney. Expand
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