Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells

@article{Wilcock1991LocalizationOP,
  title={Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells},
  author={Donna M Wilcock and David Philip Lane},
  journal={Nature},
  year={1991},
  volume={349},
  pages={429-431}
}
REPLICATIONof DNA occurs at discrete sites in eukaryotic cell nuclei, where replication proteins are clustered into large complexes, or 'replicases'1–3. Similarly, viral DNA replication is a highly structured process, notably in herpes simplex virus type-1 (HSV-1; reviewed in ref. 4) in which large globular 'replication compartments' containing the viral replication machinery exist. Replicating cellular DNA redistributes to these compartments upon HSV-1 infection5. We have now used antibodies… CONTINUE READING

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