Localization of nuclear-encoded mRNAs to mitochondria outer surface

  title={Localization of nuclear-encoded mRNAs to mitochondria outer surface},
  author={Adi Golani-Armon and Yoav Arava},
  journal={Biochemistry (Moscow)},
The diverse functions of mitochondria depend on hundreds of different proteins. The vast majority of these proteins is encoded in the nucleus, translated in the cytosol, and must be imported into the organelle. Import was shown to occur after complete synthesis of the protein, with the assistance of cytosolic chaperones that maintain it in an unfolded state and target it to the mitochondrial translocase of the outer membrane (TOM complex). Recent studies, however, identified many mRNAs encoding… CONTINUE READING