Localization of nitric oxide synthases during fracture healing.

  title={Localization of nitric oxide synthases during fracture healing.},
  author={Wei Zhu and George A. C. Murrell and Jianhao Lin and Edith M. Gardiner and Ashish D Diwan},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={17 8},
Previously, we have reported that nitric oxide synthases (NOSs), which generate NO, modulate fracture healing. However, the cellular sources of the NOS isoforms during the course of fracture healing have not been studied systematically. The purpose of this study was to localize the cellular distribution of NOS isoforms (inducible NOS [iNOS], endothelial NOS [eNOS], and neuronal NOS [bNOS]) by in situ hybridization and immunohistology after femoral fractures in rats. The iNOS signal was detected… CONTINUE READING

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