Localization of neuronal and glial glutamate transporters

  title={Localization of neuronal and glial glutamate transporters},
  author={J. Rothstein and Lee Martin and A. Levey and M. Dykes-Hoberg and R. W. Kuncl},
  • J. Rothstein, Lee Martin, +2 authors R. W. Kuncl
  • Published 1994
  • Biology, Medicine
  • Neuron
  • The cellular and subcellular distributions of the glutamate transporter subtypes EAAC1, GLT-1, and GLAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize the C-terminal domains of each transporter. On immunoblots, the antibodies specifically recognize proteins of 65-73 kDa in total brain homogenates. Immunocytochemistry shows that glutamate transporter subtypes are distributed differentially within neurons and astroglia. EAAC1 is specific for certain neurons, such… CONTINUE READING
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