Localization of myotonic dystrophy protein kinase in skeletal muscle and its alteration with disease.

@article{Dunne1996LocalizationOM,
  title={Localization of myotonic dystrophy protein kinase in skeletal muscle and its alteration with disease.},
  author={Patrick Dunne and Lijuan Ma and Daren Casey and Yadollah Harati and Henry F. Epstein},
  journal={Cell motility and the cytoskeleton},
  year={1996},
  volume={33 1},
  pages={52-63}
}
Myotonic dystrophy (DM) is an autosomal dominant disorder which affects skeletal muscle, heart, eye lens, brain, and endocrine functions. The disease-causing mutations are expansions of the triplet repeat CTG in the 3' untranslated region of a locus which encodes a serine/threonine protein kinase that represents a new family of protein kinases. A monoclonal antibody to a recombinant DM protein kinase (mAb DM-1) reacts specifically with the 64 kDa isoform of DM protein kinase in type I fibers in… CONTINUE READING