Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.

@article{Nakamura2008LocalizationOM,
  title={Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.},
  author={Yasuhiko Nakamura and Masahito Ogura and Daisuke Tanaka and Nobuya Inagaki},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={366 1},
  pages={174-9}
}
Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria. We have investigated the localization of these three SIRT proteins of mouse. SIRT3, SIRT4, and SIRT5 proteins were localized in different compartments of the mitochondria. When SIRT3 and SIRT5 were co-expressed in the cell, localization of SIRT3 protein changed from mitochondria to nucleus. These… CONTINUE READING
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